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A thread was started in CF-Community about what websites are usefully implementing Web 2.0 technologies for the betterment of the UI. One that was mentioned was Netflix and the way that the UI responds to the user in a positive way.

One of the things we have to remember in UI development is that just because we can’t doesn’t mean we should. With the advent of the CFAJAX stuff in CF8 it really expands on that. I have seen a few developers use the Ajax elements just because they thought it was cool, and in the end hinder the user experience. Good uses of AJAX is when the user doesn’t even realize it. When the user experience is so transparent that the user doesn’t even know that that there is anything “magical” going on.
It’s at that time you know you have a good UI.
Very much agree on using AJAX just for its own sake. It has to make sense.
http://www.vertabase.com/blog/amazon-and-ajax-in-interface-design/
Is a post on a good use of it, in Amazon’s holiday site.